Human B-cell isotype switching origins of IgE

Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures

Although it has been established that IL-4 enhances both IgG1 and IgE secretion in LPS-stimulated B cell cultures, these studies failed to determine whether IL-4 preferentially induces isotype switching or preferentially allows for the maturation of precommitted precursor cells. To distinguish between these possibilities, it is necessary to ascertain the effect of IL-4 on the isotypes secreted ...

Isotype Switching by Human B Cells Is

TACI and BAFF-R mediate isotype switching in B cells

The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and IgE. APRIL and BAFF each engage two receptors, transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), on B cells. In add...

Somatic Mutation , and Isotype Switching During a Memory B

Aprimary humoral immune response to most antigens results in the development of a long-lasting state of immunity. In addition to influencing the outcome of a secondary immune response to the priming antigen, this state of immunity may also alter subsequent immune responses to antigens that are structurally related to this priming antigen, a phenomenon that has been termed "original antigenic si...

Human Dendritic Cells Skew Isotype Switching of CD40-activated Naive B Cells towards IgA1 and IgA2

Within T cell-rich areas of secondary lymphoid organs, interdigitating dendritic cells recruit antigen-specific T cells that then induce B cells to secrete Igs. This study investigates the possible role(s) of dendritic cells in the regulation of human B cell responses. In the absence of exogenous cytokines, in vitro generated dendritic cells (referred to as Dendritic Langerhans cells, D-Lc) ind...